Elliya’s talk presented at the Vancouver Coast Health Research Institute’s 2017 Research Medicine Expo at Vancouver General Hospital – “Erythropoietin Signalling After Ureteral Obstruction” won Best Speaker Award!
Elliya Park is a master’s student at the Stone Centre Laboratory who work s under the supervision of Dr. Dirk Lange of Urologic Sciences. Her research at the Stone Centre focuses on erythropoietin signalling after ureteral obstruction. This research has many implications in urologic medicine with respect to recovery of the ureter after it is obstructed (in particular by kidney stones).
The Stone Centre’s 4th Annual Patient Engagement Event: “Shattering Stones – Which Treatment is Best for Me?” was another successful night in what has become a cornerstone event for the Stone Centre team and it’s patients.
The main goal of this year’s event was to educate the general community on kidney stones and in particular the treatments available for kidney stones. By educating patients on the various treatment options, the Stone Centre team wants to promote healthy and knowledgeable decision making with respect to stone disease, as well as to minimize any confusion or misunderstanding about stones. Additionally, the Stone Centre team wants to foster a sense of community between the Urologists, Researchers and Stone Patients so that no patient feels helpless or alone in their fight against kidney stones.
The event is non-profit, and is sponsored by community donors that graciously provide us with the venue, refreshments, snacks, and door prizes. We collaborate with both Vancouver Coastal Health as well as the VGH Foundation many months in advance in order to organize and provide the best event possible for our patients.
This year’s event started with a presentation on the different treatment options that the Stone Centre has to offer as explained by Urologists Dr. Ben Chew and Dr. Ryan Paterson. This presentation also included an interactive discussion with a group of 4 patient panelists that had undergone the different treatments. The patient panelists offered their unique perspectives on the treatments they had experienced, including the factors that influenced them in making their decision. This combination of information presentation and discussion was the first of its kind at this event. The discussion between the Urologists and Patient Panel was well received and provided guests with both a professional and patient perspective on different treatments as well as the various pros and cons of each treatment. (If you would like to see the animations that were shown during the presentations of each treatment please click HERE to visit our treatment options page.)
Following this presentation, Dr. Dirk Lange, the director of Basic Science at the Stone Centre, presented on the various clinical projects that are ongoing at the Stone Centre. This included interesting information on the prevalence and role of antibiotics during stone treatment surgery, in particular for infection stones (struvite) which the Stone Centre is the first to conduct. This presentation also touched on the sensitive topic of antibiotic misuse. One of the goals of the Stone Centre’s research is to determine effective, efficient and appropriate antibiotic regimes to prevent misuse and promote health and well being. (For more info on any of our antibiotics study, please click HERE to visit our active clinical trials page).
The presentation portion of the event ended with a question and answer period. Guests were invited to submit questions on slips of paper that were then answered by Dr.’s Chew, Paterson Lange and the patient panel. Raffle prizes were drawn which concluded the formal presentation portion of the event. The last half hour of the event featured a mingling session in the lobby of the Paetzold auditorium with light refreshments and snacks provided. The whole Stone Centre team from both the clinical and laboratory sides were available to answer questions from any of the guests. The Stone Centre’s dietitians – Judith Andrews and Lynn Tomita – were also available to answer the many questions about diet, prevention and stone disease.
If you would like to get involved in the Stone Centre’s ongoing research, or if you would like to get involved with the Stone Centre as a volunteer please visit our CONTACT US page where you get can in touch with us through either email or phone. If you took home a study package at the event and have any questions please feel free to contact us as well.
The Stone Centre is always looking for ways to improve its quality of care and research. If you would like to contribute an idea, or have feedback regarding the event please send us an email as well.
Thanks and Contributions:
A big thank you to the VGH Foundation for their help in organizing the event, printing materials, social media presence and helping with setup and takedown!
A big thank you to our sponsors this year who provided the snacks, refreshments and raffle draw prizes!
We look forward to seeing you all again at our next event!
“Kidney Stones: The latest on Prevention, Treatment, & Research”
We invite you to join us for the third annual Stone Centre Patient Engagement Event.
Come join the Stone Centre Team for a night of interesting presentations. Hear from an interdisciplinary care team including a urology doctor, renal dietician, and researcher. They will be discussing kidney stone prevention, healthy diet choices, and ongoing research as well as recent discoveries.
There will be time for questions after the presentations as well as some light refreshments will be served. Guests are absolutely welcome!
Date: Tuesday September 13, 2016
Time: 6:00pm – 8:30pm
*Registration is from 6:00pm-6:30pm (talks start exactly at 6:30pm so please arrive before then)*
Location: Vancouver General Hospital, Jim Pattison Pavilion, Paetzold Education Centre, 889 W 12 Avenue, Vancouver, BC V5Z 1M9
RSVP: please RSVP by contacting the Stone Centre research team or signing up online.
Sullivan Research Day was an all day educational program hosted at the Paetzold auditorium at VGH on June 21, 2016. This event featured various lecturers that were invited to talk about their respective research in the field of urology. These lectures included presentations from Doctors, residents, fellows, and students in a variety of topics such as clinical research, cell plasticity and treatment resistance, genomics and bioinformatics, metabolism, and novel diagnostics and therapeutics as they pertain to various cancers.
One of the Stone Centre’s very own students – David Choy – was selected to present his ongoing metagenomics research project at this prestigious event.
Here is a short brief on the presentation…
“The Relationship between Bacterial Enzyme Pathways in the Gut and Metabolic Imbalances in Kidney Stone Patients”
Introduction: In kidney stone disease (KSD), patients suffer from excess absorption/production of oxalate that combines with calcium in the kidney to form calcium oxalate stones. In this study, we want to find out how the bacteria in the gut microbiome use their metabolic enzymes to regulate oxalate and other metabolites in and across the gut.
Methods: Fecal samples were collected from 17 patients with calcium oxalate kidney stones and their non-stone forming healthy spouses. DNA is extracted from the fecal samples and shotgun-sequence using Illumina HiSeq and the NexteraXT metagenomics library kit. The DNA sequences were then aligned to five gene databases to obtain meaningful annotations. The DNA was also sequence specifically for 16s_rRNA genes to identify the bacteria present.
Results: Metagenomics sequencing results show that patients and controls had different prevalences of genes involved in glyoxylate, butyrate, and vitamin metabolism. These pathways play a role in oxalate and calcium regulation because glyoxylate is a precursor for oxalate in hepatocytes, butyrate promotes the integrity of the colonocyte gut lining and therefore absorption of ions across the gut, and vitamin metabolism regulates calcium absorption respectively. These observations are further supported by 16s_rRNA data that showed controls had a higher prevalence of butyrate-producing bacteria of the Lachnospiriceae and Ruminococcaceae family. Additionally, we found that patients did not have any Oxalobacter formigenes (a well-known oxalate degrading bacteria) in their gut while most controls did.
Conclusions: These results suggest that bacterial enzymes play a role in regulating the absorption, degradation and secretion of oxalate in the gut whether by directly degrading oxalate or by affecting other metabolites. Further study may uncover targets in bacterial enzyme pathways for treatment of metabolic disorders like KSD.